Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity

S.      Agatonovic-Kustrin; J.   V.   Turner

doi:10.2174/138955708785132747

Abstract

This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.

Keywords: Computer aided drug design, molecular modeling, structure-activity relationship, hormones, drug design, structure, QSAR, phytoestrogens