Urea and Acid Induced Unfolding of Fatted and Defatted Human Serum Albumin

Title: Urea and Acid Induced Unfolding of Fatted and Defatted Human Serum Albumin

Volume: 15 Issue: 8

Author(s): Parveen Salahuddin

Affiliation:

Keywords: Acid induced unfolding, conformational stability, hydrodynamic volume, intrinsic viscosity, urea induced unfolding

Abstract: Urea induced equilibrium unfolding of fatted and defatted human serum albumin (HSA) showed that fatty acid stabilizes native and intermediate states. Similarly acid induced unfolding of fatted and defatted HSA also showed that fatty acid stabilizes NF and FE transitions. These results also showed that five electrostatic interactions along with one buried carboxyl group of acidic amino acid are involved in acid induced unfolding of HSA.

Cite this article as:

Salahuddin Parveen, Urea and Acid Induced Unfolding of Fatted and Defatted Human Serum Albumin, Protein & Peptide Letters 2008; 15 (8) . https://dx.doi.org/10.2174/092986608785203764

DOI https://dx.doi.org/10.2174/092986608785203764	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305