Luminescence and Photophysical Properties of Benzo[a]phenothiazines - Therapeutic, Physico-Chemical, and Analytical Applications

Title: Luminescence and Photophysical Properties of Benzo[a]phenothiazines - Therapeutic, Physico-Chemical, and Analytical Applications

Volume: 7 Issue: 9

Author(s): Mame Diabou Gaye-Seye, Jean-Jacques Aaron, Cyril Parkanyi and Noboru Motohashi

Affiliation:

Keywords: Benzo[a]phenothiazines, luminescence, dipole moments, cyclodextrins (CDs) inclusion complexes, analytical applications

Abstract: Luminescence studies on a series of new 12H-benzo[a]phenothiazines (BPHTs), possessing potentially useful antitumor therapeutic properties, are reviewed. The electronic absorption and fluorescence spectral properties of BPHTs, as well as their triplet- and singlet- excited states luminescence quenching are reviewed. Ground-state and singlet-excited state dipole moments and solvatochromic relationships are also described for these compounds. Studies on the formation of inclusion complexes between BPHTs and cyclodextrins (CDs), including CD-enhanced fluorescence, and thermodynamic constants and molecular geometry of these complexes, are discussed. The BPHTs antitumor properties in relation to their π-electron density, and the physico-chemical and analytical applications based on their fluorescence and photophysical properties are also presented. This review article is based on selected literature data published in the last ten years (1993-2004).

Cite this article as:

Diabou Gaye-Seye Mame, Aaron Jean-Jacques, Parkanyi Cyril and Motohashi Noboru, Luminescence and Photophysical Properties of Benzo[a]phenothiazines - Therapeutic, Physico-Chemical, and Analytical Applications, Current Drug Targets 2006; 7 (9) . https://dx.doi.org/10.2174/138945006778226606