Synthesis of Two Peptide Mimetics as Markers for Chemical Changes of Wools Keratin During Skin Unhairing Process

Title: Synthesis of Two Peptide Mimetics as Markers for Chemical Changes of Wools Keratin During Skin Unhairing Process

Volume: 15 Issue: 4

Author(s): Dantcho Danalev, Margarita Koleva, Dimitrina Ivanova, Lyubomir Vezenkov and Nikolay Vassilev

Affiliation:

Keywords: Peptides mimetics, Unnatural amino acids, Hides' and skins' unhairing

Abstract: The sheep skins unhairing process with preliminary alkaline treatment of the wool leads to two unnatural dipeptide mimetics lysinoalanine (Lys* - Ala) and ornithinoalanine (Orn*- Ala) obtaining. They are result from the keratin hydrolysis process. The changes of wool keratin make it resistant to sulphide degradation. We synthesized and characterized these unnatural dipeptides under the experimental conditions. The structures and mechanism of Lys* - Ala and Orn*- Ala obtaining were elucidated. The using of newly synthesized products as markers for control of wools keratin changes during skin unhairing process was demonstrated. The developments have also been the result of economic and environmental pressures to meet environmental regulations.

Cite this article as:

Danalev Dantcho, Koleva Margarita, Ivanova Dimitrina, Vezenkov Lyubomir and Vassilev Nikolay, Synthesis of Two Peptide Mimetics as Markers for Chemical Changes of Wools Keratin During Skin Unhairing Process, Protein & Peptide Letters 2008; 15 (4) . https://dx.doi.org/10.2174/092986608784246489

DOI https://dx.doi.org/10.2174/092986608784246489	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305