E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment

Title: E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment

Volume: 8 Issue: 5

Author(s): E. W. Howard, K. D. Camm, Y. C. Wong and X. H. Wang

Affiliation:

Keywords: E-cadherin, cell adhesion, epithelial-mesenchymal transition, epigenetics, transcriptional repressors, chemotherapy, metastasis, cancer

Abstract: We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.

Cite this article as:

Howard W. E., Camm D. K., Wong C. Y. and Wang H. X., E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223521