Asymmetric Synthesis of α-Unsubstituted β-Hydroxy Acids

Title: Asymmetric Synthesis of α-Unsubstituted β-Hydroxy Acids

Volume: 5 Issue: 2

Author(s): Jan Spengler and Fernando Albericio

Affiliation:

Keywords: 3-hydroxycarboxylic acids, asymmetric aldol reactions, Reformatsky reactions, asymmetric reduction, Arndt-Eistert homologation, β-lactones, cyclic sulfites, cyclic sulfates, reductive cleavage

Abstract: α-Unsubstituted β-hydroxy acids (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids.

Cite this article as:

Spengler Jan and Albericio Fernando, Asymmetric Synthesis of α-Unsubstituted β-Hydroxy Acids, Current Organic Synthesis 2008; 5 (2) . https://dx.doi.org/10.2174/157017908784221558