Sialoglycotherapeutics in Protozoal Diseases

Angana      Ghoshal; Sumi   Mukhopadhyay   nee Bandyopadhyay; Chitra      Mandal

doi:10.2174/138955708783955980

Abstract

The manipulation of glycosylation, mainly sialylation, holds enormous potential for understanding the biological functions of glycoproteins and glycolipids to treat many diseases. The existing knowledge in the field of glycobiology is exploited by glycotherapeutics for combating protozoan diseases. This review focuses on the development of novel glycobiological therapeutic strategies in the field of protozoan infections.

Keywords: Anti-O-acetylated sialoglycoprotein specific antibodies, anti-α-gal antibodies, carbohydrate engineering, drug delivery, engineering inhibitors of glycoproteins, glycotherapeutics, glycovaccine, immunotoxin, metabolite oligosaccharide engineering, oligosaccharide engineering