Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury

Title: Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury

Volume: 8 Issue: 4

Author(s): P. C. Burcham, L. M. Kaminskas, D. Tan and S. M. Pyke

Affiliation:

Keywords: Carbonyl stress, acrolein, protein adducts, hydralazine

Abstract: This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to “carbonyl stress” during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.

Cite this article as:

Burcham C. P., Kaminskas M. L., Tan D. and Pyke M. S., Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury, Mini-Reviews in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/138955708783955953