Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine

Title: Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine

Volume: 8 Issue: 4

Author(s): Cato T. Laurencin, Tao Jiang, Sangamesh G. Kumbar and Lakshmi S. Nair

Affiliation:

Keywords: Chitosan, bioactive, biomolecules, scaffolds, surface modification, tissue engineering, regenerative medicine

Abstract: Biodegradable polymeric scaffolds are widely used as a temporary extracellular matrix in tissue engineering and regenerative medicine. By physical adsorption of biomolecules on scaffold surface, physical entrapment of biomolecules in polymer microspheres or hydrogels, and chemical immobilization of oligopeptides or proteins on biomaterials, biologically active biomaterials and scaffolds can be derived. These bioactive systems show great potential in tissue engineering in rendering bioactivity and/or specificity to scaffolds. This review highlights some of the biologically active chitosan systems for tissue engineering application and the associated strategies to develop such bioactive chitosan systems.

Cite this article as:

Laurencin T. Cato, Jiang Tao, Kumbar G. Sangamesh and Nair S. Lakshmi, Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine, Current Topics in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/156802608783790974