Malaria Combination Therapies: Advantages and Shortcomings

A.      Martinelli; R.      Moreira; P.   V.L.   Cravo

doi:10.2174/138955708783744092

Abstract

Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

Keywords: Malaria, drug resistance, drug combination therapy, artemisinin, quinolines, antifolates

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Mini-Reviews in Medicinal Chemistry

Title: Malaria Combination Therapies: Advantages and Shortcomings

Volume: 8 Issue: 3

Author(s): A. Martinelli, R. Moreira and P. V.L. Cravo

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Keywords: Malaria, drug resistance, drug combination therapy, artemisinin, quinolines, antifolates

Abstract: Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

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Martinelli A., Moreira R. and Cravo V.L. P., Malaria Combination Therapies: Advantages and Shortcomings, Mini-Reviews in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/138955708783744092