Synthesis of 13C and 15N Isotope Labeled Triazine Inhibitors for the Mechanistic Study of Dihydropteridine Reductase

Jeonghee      Kang; Ruel   Z.B.   Desamero

doi:10.2174/157017808783743993

Abstract

¹³C and ¹⁵N isotope labeled precursors and 6-amino-2,3-dimethylpyrimido[4,5-e][1,2,4] triazine-8-one were synthesized for the mechanistic study of dihydropteridine reductase (DHPR). Structures of precursors and the inhibitors were confirmed by UV/Vis, ¹³C NMR, and ESI-MS measurements.

Keywords: ¹³C and ¹⁵N isotope labeling, dihydropteridine reductase inhibitor, pyrimido[4, 5-e][1, 2, 4] triazine-8-one.

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Letters in Organic Chemistry

Title:Synthesis of ¹³C and ¹⁵N Isotope Labeled Triazine Inhibitors for the Mechanistic Study of Dihydropteridine Reductase

Volume: 12 Issue: 9

Author(s): Jeonghee Kang and Ruel Z.B. Desamero

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Keywords: ¹³C and ¹⁵N isotope labeling, dihydropteridine reductase inhibitor, pyrimido[4, 5-e][1, 2, 4] triazine-8-one.

Abstract: ¹³C and ¹⁵N isotope labeled precursors and 6-amino-2,3-dimethylpyrimido[4,5-e][1,2,4] triazine-8-one were synthesized for the mechanistic study of dihydropteridine reductase (DHPR). Structures of precursors and the inhibitors were confirmed by UV/Vis, ¹³C NMR, and ESI-MS measurements.

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Kang Jeonghee and Desamero Z.B. Ruel, Synthesis of ¹³C and ¹⁵N Isotope Labeled Triazine Inhibitors for the Mechanistic Study of Dihydropteridine Reductase, Letters in Organic Chemistry 2015; 12 (9) . https://dx.doi.org/10.2174/157017808783743993