A New, Readily Available Double-Component System for Asymmetric Henry Reaction

Title: A New, Readily Available Double-Component System for Asymmetric Henry Reaction

Volume: 5 Issue: 2

Author(s): Zixing Shan and Wuzu Ha

Affiliation:

Keywords: Asymmetric synthesis, double-component catalytic system, chiral amino alcohol, C-C bond formation, Henry reaction, β-nitroalcohol

Abstract: A new, readily available double-component catalytic system for asymmetric Henry reaction has been discovered. The aromatic aldehydes reacted with nitromethane in THF under catalysis of threo-(1S, 2S)-TDMANPCu( OAc)2.H2O system to furnish β-nitro alcohols in good yields and up to 79% ee. This methodology is air-tolerant and easily operative, and the chiral amino alcohol can be conveniently synthesized from inexpensive chiral starting material.

Cite this article as:

Shan Zixing and Ha Wuzu, A New, Readily Available Double-Component System for Asymmetric Henry Reaction, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743876