Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

Title: Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

Volume: 8 Issue: 1

Author(s): Yves Mely, Hugues de Rocquigny, Volodymyr Shvadchak, Sergiy Avilov, Chang Zhi Dong, Ursula Dietrich and Jean-Luc Darlix

Affiliation:

Keywords: NCp7, zinc ejector, library, HIV, structure, peptidomimetic, aptamer, intercalator

Abstract: The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.

Cite this article as:

Mely Yves, Rocquigny de Hugues, Shvadchak Volodymyr, Avilov Sergiy, Dong Zhi Chang, Dietrich Ursula and Darlix Jean-Luc, Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy, Mini-Reviews in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/138955708783331603