Interaction of Calreticulin with Amyloid Beta Peptide 1-42

Title: Interaction of Calreticulin with Amyloid Beta Peptide 1-42

Volume: 15 Issue: 1

Author(s): G. Houen, K. Duus and P. R. Hansen

Affiliation:

Keywords: Calreticulin, chaperone, amyloid beta, Alzheimer disease

Abstract: The interaction of calreticulin with amyloid beta (Aβ) was investigated using solid phase and solution binding assays. Calreticulin bound Aβ 1-42 in a time and concentration dependent fashion. The binding was optimal at pH 5 and was stimulated by Ca2+ and inhibited by Zn2+ at pH 7. Interaction took place through the hydrophobic C-terminus of Aβ 1- 42 and the polypeptide binding site of calreticulin. The results are discussed in the light of a reported role of calreticulin as a cell surface scavenger receptor.

Cite this article as:

Houen G., Duus K. and Hansen R. P., Interaction of Calreticulin with Amyloid Beta Peptide 1-42, Protein & Peptide Letters 2008; 15 (1) . https://dx.doi.org/10.2174/092986608783330459

DOI https://dx.doi.org/10.2174/092986608783330459	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305