Conjugation of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetracetic Acid (DOTA) and its Derivatives to Peptides: Synthesis, Applications and Future Prospects

Title: Conjugation of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetracetic Acid (DOTA) and its Derivatives to Peptides: Synthesis, Applications and Future Prospects

Volume: 4 Issue: 4

Author(s): Z. Kovacs and L. M. De Leon-Rodriguez

Affiliation:

Keywords: DOTA, peptides, conjugation, labeling, diagnostic, therapy

Abstract: The universal chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid (DOTA) and its bifunctional derivatives are widely used to label peptides with various metal ions for biomedical applications. Bifunctional DOTA derivatives and their conjugation to peptides has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals. This review covers the synthesis of DOTA-peptide conjugates, their potential use in biomedicine and the problems related to their applications.

Cite this article as:

Kovacs Z. and De Leon-Rodriguez M. L., Conjugation of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetracetic Acid (DOTA) and its Derivatives to Peptides: Synthesis, Applications and Future Prospects, Mini-Reviews in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157019307782411671