Recent Advances in the Medicinal Chemistry of Polyamine Toxins

Title: Recent Advances in the Medicinal Chemistry of Polyamine Toxins

Volume: 1 Issue: 4

Author(s): Kristian Stromgaard, Kim Andersen, Povl Krogsgaard-Larsen and Jerzy W. Jaroszewski

Affiliation:

Keywords: Polyamine Toxins, Synthesis, Argiope lobata, Nephilia clavata, Nephilia maculata, Dolomedes okefinokensis, Hebestatis theveniti, Hololenta curta, Araneidae, Philanthus triangulum

Abstract: This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity, photolabeling studies using polyamine toxins as templates, as well as use of solid phase methods for the synthesis of polyamine toxins. The review is mainly concerned with effects of polyamine toxins on nicotinic acetylcholine receptors and ionotropic glutamate receptors.

Cite this article as:

Stromgaard Kristian, Andersen Kim, Krogsgaard-Larsen Povl and Jaroszewski W. Jerzy, Recent Advances in the Medicinal Chemistry of Polyamine Toxins, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406738