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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Triazine Conjugates for Multiple Site-Specific Labeling of Peptides

Author(s): Jonathan A. Zerkowski and Douglas A. Schftner

Volume 8, Issue 2, 2001

Page: [123 - 129] Pages: 7

DOI: 10.2174/0929866013409562

Price: $65

Abstract

Mono- and di-substituted triazines were appended to the side chain of lysine or ornithine, which was then used in the synthesis of peptides. In this way, environment-sensitive reporter groups can be included in a sequence-specific manner in a peptide. The triazine adducts are stable to standard conditions employed in peptide synthesis. Several model peptides showing the utility of these conjugates were prepared

Keywords: triazine, peptides, aminochlorotriszines, fluorophores, ornithine


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