DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Title: DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Volume: 1 Issue: 1

Author(s): Philip J. Perry and Terence C. Jenkins

Affiliation:

Keywords: DNA Tetraplex, Antitumour Telomerase, nucleic acid biotargets, malignant transformation, covalent fixation processes, chemotherapeutic target, Guanine rich, telomerase activity, isothermal titration calorimetry, stacked G tetrads, mesoporphyrin NMM dye

Abstract: Four-stranded tetraplex (“G-quadruplex”) DNA represents a new paradigm for the design of DNA-interactive antitumour drugs, as the formed DNA-drug complexes have been suggested to interfere with critical telomerase function. The unique structural features presented by tetraplex over duplex DNA have stimulated the design of small ligand molecules able to selectively promote the formation and-or stabilisation of such higher-order DNA structures. Current developments in tetraplex-targeted telomerase inhibitors, and importantly their DNA structural selectivity, are explored.

Cite this article as:

Perry J. Philip and Jenkins C. Terence, DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition, Mini-Reviews in Medicinal Chemistry 2001; 1 (1) . https://dx.doi.org/10.2174/1389557013407304