Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues

Title: Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues

Volume: 2 Issue: 6

Author(s): Dae-Kee Kim and Namkyu Lee

Affiliation:

Keywords: topoisomerase, camptothecin, structural features of human topo enzyme, structure-activity relationship, monomeric protein, lurtotecan, rubitecan, highly lipophilic

Abstract: The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.

Cite this article as:

Kim Dae-Kee and Lee Namkyu, Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405530