Malaria: New Chemotherapeutic Peroxide Drugs

Kristina      Borstnik; Ik-hyeon      Paik; Gary   H.   Posner

doi:10.2174/1389557023405620

Abstract

Chemical insights into artemisinins biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.

Keywords: malaria, chemotherapeutic peroxide drugs, artemisinin biological mechanism, malaria chemotherapy, antimalarial peroxide artemisinin, anopheline mosquitoes, host bloodstream, aggregation, acute encephalopathy

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Mini-Reviews in Medicinal Chemistry

Title: Malaria: New Chemotherapeutic Peroxide Drugs

Volume: 2 Issue: 6

Author(s): Kristina Borstnik, Ik-hyeon Paik and Gary H. Posner

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Abstract: Chemical insights into artemisinins biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.

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Borstnik Kristina, Paik Ik-hyeon and Posner H. Gary, Malaria: New Chemotherapeutic Peroxide Drugs, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405620