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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery

Author(s): Yves Landry and J. P. Gies

Volume 2, Issue 4, 2002

Page: [361 - 372] Pages: 12

DOI: 10.2174/1389557023405945

Price: $65

Abstract

Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their a and bg subunits to effectors including adenylylcyclases, ion channels, phospholipases Cb, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.

Keywords: heterotrimeric g protein, transmambrane signaling, heptahelical receptor, r g s protein


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