Abstract
Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their a and bg subunits to effectors including adenylylcyclases, ion channels, phospholipases Cb, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.
Keywords: heterotrimeric g protein, transmambrane signaling, heptahelical receptor, r g s protein
Mini-Reviews in Medicinal Chemistry
Title: Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery
Volume: 2 Issue: 4
Author(s): Yves Landry and J. P. Gies
Affiliation:
Keywords: heterotrimeric g protein, transmambrane signaling, heptahelical receptor, r g s protein
Abstract: Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their a and bg subunits to effectors including adenylylcyclases, ion channels, phospholipases Cb, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.
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Cite this article as:
Landry Yves and Gies P. J., Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023405945
DOI https://dx.doi.org/10.2174/1389557023405945 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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