Melatonin and Circadian Rhythms

David   J.   Kennaway; Helen      Wright

doi:10.2174/1568026023394380

Abstract

Melatonin synthesis and secretion by the pineal gland is under the control of the suprachiasmatic nucleus and consequently has a profound circadian rhythm. In this review we discuss some of the issues surrounding the measurement of melatonin rhythmicity in biological fluids and the factors that influence melatonin circadian rhythmicity, including light and drugs. We also review the role of melatonin rhythmicity in sleep timing and sleep initiation.

Keywords: Circadian Rhythms, melatonin rhythmicity, N-methyl-D-aspartate

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Current Topics in Medicinal Chemistry

Title: Melatonin and Circadian Rhythms

Volume: 2 Issue: 2

Author(s): David J. Kennaway and Helen Wright

Affiliation:

Keywords: Circadian Rhythms, melatonin rhythmicity, N-methyl-D-aspartate

Abstract: Melatonin synthesis and secretion by the pineal gland is under the control of the suprachiasmatic nucleus and consequently has a profound circadian rhythm. In this review we discuss some of the issues surrounding the measurement of melatonin rhythmicity in biological fluids and the factors that influence melatonin circadian rhythmicity, including light and drugs. We also review the role of melatonin rhythmicity in sleep timing and sleep initiation.

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Kennaway J. David and Wright Helen, Melatonin and Circadian Rhythms, Current Topics in Medicinal Chemistry 2002; 2 (2) . https://dx.doi.org/10.2174/1568026023394380