Effects of Stereochemistry of Sugars on Protein Stabilities

Kiyonari      Masumoto; Tadashi      Ueda; Makiko      Nagata; Yuko      Yamada; Yuichiro      Yoshida; Yoshio      Hashimoto; Taiji      Imoto

doi:10.2174/0929866023408553

Abstract

We investigated thermal stabilities of four proteins in the presence of four kinds of sugars to analyze the mechanism of stabilization of proteins by additives. These proteins were stabilized by the addition of sugars, and the degree of stabilization correlated to the partial molar isentropic compressibility of the sugar.

Keywords: STEREOCHEMISTRY, molar isentropic, thermophile, polyols, lysozyme, exothermic reactions

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Protein & Peptide Letters

Title: Effects of Stereochemistry of Sugars on Protein Stabilities

Volume: 9 Issue: 5

Author(s): Kiyonari Masumoto, Tadashi Ueda, Makiko Nagata, Yuko Yamada, Yuichiro Yoshida, Yoshio Hashimoto and Taiji Imoto

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Keywords: STEREOCHEMISTRY, molar isentropic, thermophile, polyols, lysozyme, exothermic reactions

Abstract: We investigated thermal stabilities of four proteins in the presence of four kinds of sugars to analyze the mechanism of stabilization of proteins by additives. These proteins were stabilized by the addition of sugars, and the degree of stabilization correlated to the partial molar isentropic compressibility of the sugar.

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Masumoto Kiyonari, Ueda Tadashi, Nagata Makiko, Yamada Yuko, Yoshida Yuichiro, Hashimoto Yoshio and Imoto Taiji, Effects of Stereochemistry of Sugars on Protein Stabilities, Protein & Peptide Letters 2002; 9 (5) . https://dx.doi.org/10.2174/0929866023408553