Recent Advances in the Identification and Development of 20S Proteasome Inhibitors

Title: Recent Advances in the Identification and Development of 20S Proteasome Inhibitors

Volume: 2 Issue: 3

Author(s): Carlos Garcia-Echeverria

Affiliation:

Keywords: 20s proteasome inhibitor, anti-inflammatory agent

Abstract: The involvement of the 20S proteasome in the degradation of critical intracellular regulatory proteins has suggested the potential use of proteasome inhibitors as novel anti-inflammatory agents and for the treatment of cancer and auto-immune diseases. Early inhibitors of the 20S proteasome were relatively nonspecific compounds and used for in vitro studies of the ubiquitin / proteasome-dependent degradation pathway. The inherent drawbacks of these inhibitors (e.g., non-target specific, too reactive or unstable) has prompted medicinal chemists to search for alternative subunit-specific proteasome inhibitors. This manuscript summarises recent salient medicinal chemistry achievements in this area of research.

Cite this article as:

Garcia-Echeverria Carlos, Recent Advances in the Identification and Development of 20S Proteasome Inhibitors, Mini-Reviews in Medicinal Chemistry 2002; 2 (3) . https://dx.doi.org/10.2174/1389557023406142