Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups

Jih   Ru   Hwu; Krishna   S.   Ethiraj; Gholam   H.   Hakimelahi

doi:10.2174/1389557033488132

Abstract

This Review contains our recent studies on evaluation of biological activities associated with monocyclic β-lactams and bicyclic β-lactam antibiotics containing various heteroatoms. A series of bicyclic β-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These β-lactams exhibited enhanced antibacterial activity.

Keywords: bicyclic lactams, monocyclic lactams, lactam antibiotics, antibacterial activity

« Previous Next »

Rights & Permissions Print Cite

Mini-Reviews in Medicinal Chemistry

Title: Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups

Volume: 3 Issue: 4

Author(s): Jih Ru Hwu, Krishna S. Ethiraj and Gholam H. Hakimelahi

Affiliation:

Keywords: bicyclic lactams, monocyclic lactams, lactam antibiotics, antibacterial activity

Abstract: This Review contains our recent studies on evaluation of biological activities associated with monocyclic β-lactams and bicyclic β-lactam antibiotics containing various heteroatoms. A series of bicyclic β-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These β-lactams exhibited enhanced antibacterial activity.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Hwu Ru Jih, Ethiraj S. Krishna and Hakimelahi H. Gholam, Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups, Mini-Reviews in Medicinal Chemistry 2003; 3 (4) . https://dx.doi.org/10.2174/1389557033488132