Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines

Takashi      Mino; Youichi      Tanaka; Youtaro      Hattori; Motoko      Tanaka; Masami      Sakamoto; Tsutomu      Fujita

doi:10.2174/1570178043488699

Abstract

2-(1-indolinyl)benzaldehyde dimethylhydrazones are prepared by nucleophilic aromatic substitution of the corresponding 2-fluorobenzaldehyde dimethylhydrazones with lithiated indoline in good yields.

Keywords: hydrazone, indoline, nucleophilic aromatic substitution, atropisomer, aminophosphine

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Letters in Organic Chemistry

Title: Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines

Volume: 1 Issue: 1

Author(s): Takashi Mino, Youichi Tanaka, Youtaro Hattori, Motoko Tanaka, Masami Sakamoto and Tsutomu Fujita

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Keywords: hydrazone, indoline, nucleophilic aromatic substitution, atropisomer, aminophosphine

Abstract: 2-(1-indolinyl)benzaldehyde dimethylhydrazones are prepared by nucleophilic aromatic substitution of the corresponding 2-fluorobenzaldehyde dimethylhydrazones with lithiated indoline in good yields.

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Mino Takashi, Tanaka Youichi, Hattori Youtaro, Tanaka Motoko, Sakamoto Masami and Fujita Tsutomu, Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488699