Reactions in Unusual Media

Daniel      Clarke; Mohammed   A.   Ali; Anthony   A.   Clifford; Andrew      Parratt; Paul      Rose; Dominik      Schwinn; Willi      Bannwarth; Christopher   M.   Rayner

doi:10.2174/1568026043451096

Abstract

This review provides an introduction to three of the most well-developed solvent replacement strategies currently under investigation for synthetic chemistry: Ionic liquids, fluorous phase techniques, and supercritical carbon dioxide. They are all fascinating reaction media, and have considerable potential for use in pharmaceutical synthesis. However, this has to be balanced with problems and limitations of the new methods. This review aims to provide an overall account of recent advances in the use of unusual media for synthetic chemistry, with an emphasis on highlighting potential benefits, but also limitations, of each of the methods described.

Keywords: pharmaceutical synthesis, carbondioxide, Ionic liquids, solvent

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Current Topics in Medicinal Chemistry

Title: Reactions in Unusual Media

Volume: 4 Issue: 7

Author(s): Daniel Clarke, Mohammed A. Ali, Anthony A. Clifford, Andrew Parratt, Paul Rose, Dominik Schwinn, Willi Bannwarth and Christopher M. Rayner

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Keywords: pharmaceutical synthesis, carbondioxide, Ionic liquids, solvent

Abstract: This review provides an introduction to three of the most well-developed solvent replacement strategies currently under investigation for synthetic chemistry: Ionic liquids, fluorous phase techniques, and supercritical carbon dioxide. They are all fascinating reaction media, and have considerable potential for use in pharmaceutical synthesis. However, this has to be balanced with problems and limitations of the new methods. This review aims to provide an overall account of recent advances in the use of unusual media for synthetic chemistry, with an emphasis on highlighting potential benefits, but also limitations, of each of the methods described.

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Clarke Daniel, Ali A. Mohammed, Clifford A. Anthony, Parratt Andrew, Rose Paul, Schwinn Dominik, Bannwarth Willi and Rayner M. Christopher, Reactions in Unusual Media, Current Topics in Medicinal Chemistry 2004; 4 (7) . https://dx.doi.org/10.2174/1568026043451096