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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Urocortin: Cardiovascular Actions and Therapeutic Implications

Author(s): M. T. Rademaker

Volume 1, Issue 2, 2004

Page: [168 - 172] Pages: 5

DOI: 10.2174/1570180043485482

Price: $65

Abstract

Urocortin, expressed throughout the heart and vasculature, has potent effects on the cardiovascular system including vasodilation, increases in cardiac contractility and coronary blood flow, and protection of the myocardium against ischemia / reperfusion damage. This range of actions suggests urocortin has therapeutic potential in states of cardiac dysfunction and injury.

Keywords: urocortin, heart, vasculature, vasodilation, inotropism, cardioprotection


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