Synthesis and Stability of 1-Phenylethenyl Phosphate Derivatives and their Phosphoryl Transfer Activity

Tomohisa      Moriguchi; Kazuhisa      Okada; Kohji      Seio; Mitsuo      Sekine

doi:10.2174/1570178043488482

Abstract

1-Phenylethenyl phosphate derivatives of the monoester type were synthesized via the Perkow reaction. Among them, 2-(2,4-difluorophenyl)ethenyl phosphate was found to be obtained as a pure salt. It turned out that this compound and 2-phenylethenyl phosphate can transfer their phosphoryl groups to AMP in pyridine at elevated temperatures to give ADP.

Keywords: enol phosphate, phosphoryl transfer, phosphorylation, perkow reaction

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Letters in Organic Chemistry

Title: Synthesis and Stability of 1-Phenylethenyl Phosphate Derivatives and their Phosphoryl Transfer Activity

Volume: 1 Issue: 2

Author(s): Tomohisa Moriguchi, Kazuhisa Okada, Kohji Seio and Mitsuo Sekine

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Keywords: enol phosphate, phosphoryl transfer, phosphorylation, perkow reaction

Abstract: 1-Phenylethenyl phosphate derivatives of the monoester type were synthesized via the Perkow reaction. Among them, 2-(2,4-difluorophenyl)ethenyl phosphate was found to be obtained as a pure salt. It turned out that this compound and 2-phenylethenyl phosphate can transfer their phosphoryl groups to AMP in pyridine at elevated temperatures to give ADP.

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Moriguchi Tomohisa, Okada Kazuhisa, Seio Kohji and Sekine Mitsuo, Synthesis and Stability of 1-Phenylethenyl Phosphate Derivatives and their Phosphoryl Transfer Activity, Letters in Organic Chemistry 2004; 1 (2) . https://dx.doi.org/10.2174/1570178043488482