Matrix Metalloproteinases and Colon Anastomosis Repair: A New Indication for Pharmacological Inhibition?

M.   S.   Agren; L.   N.   Jorgensen; J.-   M.   Delaisse

doi:10.2174/1389557043403657

Abstract

Excessive matrix metalloproteinase activities have been implicated in the pathogenesis of intestinal anastomotic dehiscence, a serious and potentially life-threatening complication following gastrointestinal surgery. In this review, the properties of matrix metalloproteinases are summarized followed by presentation of clinical therapeutic interventions with synthetic matrix metalloproteinase inhibitors and novel experimental data on colon anastomosis repair that warrant exploration of these drugs in surgical colorectal patients.

Keywords: proteinases, wound healing, colorectal carcinoma, colorectal surgery, anastomosis, collagenolysis, collagen, hydroxamate inhibitors