Assembly In Vitro of Tau Protein and its Implications in Alzheimers Disease

Title: Assembly In Vitro of Tau Protein and its Implications in Alzheimers Disease

Volume: 1 Issue: 2

Author(s): Jesus Avila, Mar Perez, Jose J. Lucas, Alberto Gomez-Ramos, Ismael Santa Maria, Francisco Moreno, Mark Smith, George Perry and Felix Hernandez

Affiliation:

Keywords: tau, assembly, polyanions, fatty acids and derivates

Abstract: Tau is a microtubule associated protein that is also the main component of the aberrant filaments that form aberrant structures like the neuropil threads or the neurofibrillary tangles, found in the brain of Alzheimers disease patients. The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized.

Cite this article as:

Avila Jesus, Perez Mar, Lucas J. Jose, Gomez-Ramos Alberto, Maria Santa Ismael, Moreno Francisco, Smith Mark, Perry George and Hernandez Felix, Assembly In Vitro of Tau Protein and its Implications in Alzheimers Disease, Current Alzheimer Research 2004; 1 (2) . https://dx.doi.org/10.2174/1567205043332207