Abstract
Quinone methides (QMs) are reactive intermediates involved in a large number of chemical and biological processes such as enzyme inhibition, DNA alkylation and cross-linking. Their electrophilicity towards amines, thiols, water, amino acids and peptides has been kinetically measured in aqueous solution. The alkylation process is often thermally and photochemically reversible and the resulting adducts may act as QM carriers.
Keywords: quinone methide electrophilicity, dna alkylation and enzyme inhibition
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
10