Specific and Non-Specific Contacts in Protein Crystals

Title: Specific and Non-Specific Contacts in Protein Crystals

Volume: 11 Issue: 4

Author(s): Feng Dan and Zeng Zong-Hao

Affiliation:

Keywords: crystal structure, interface, statistical analysis, specificity of interface

Abstract: Statistical analysis of protein-protein interfaces in a database of pure peptide crystals shows that the distribution of the contact area contains two components: a major exponential distribution and a minor flat distribution. Analysis of two sub-databases provides evidence that the two components represent specific and non-specific contacts, respectively. The probability of an interface with a given area being specific can be estimated. A scaled quantity (contact ratio) is introduced that is more useful than contact area for discriminating specific and non-specific contacts in protein crystals.

Cite this article as:

Dan Feng and Zong-Hao Zeng, Specific and Non-Specific Contacts in Protein Crystals, Protein & Peptide Letters 2004; 11 (4) . https://dx.doi.org/10.2174/0929866043406959

DOI https://dx.doi.org/10.2174/0929866043406959	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305