DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs

A.      Kuzuya; J.-   M.   Zhou; M.      Komiyama

doi:10.2174/1570193043488999

Abstract

Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.

Keywords: snp genotyping, rna, pna, selective scission, acridine, nuclease

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Mini-Reviews in Organic Chemistry

Title: DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs

Volume: 1 Issue: 1

Author(s): A. Kuzuya, J.- M. Zhou and M. Komiyama

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Keywords: snp genotyping, rna, pna, selective scission, acridine, nuclease

Abstract: Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.

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Kuzuya A., Zhou M. J.- and Komiyama M., DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs, Mini-Reviews in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570193043488999