Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

Martin      Brunner; Thomas      Straub; Pauli      Saarenketo; Kari      Rissanen; Ari   M. P.   Koskinen

doi:10.2174/1570178043400929

Abstract

Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine- 3,4-dicarboxylate (1a / b) is reported. The relative and absolute configuration of the methylated products was assigned by NOESY and confirmed by a crystal structure of 1a.

Keywords: amino acids, alkylation, diastereoselectivity

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

Volume: 1 Issue: 3

Author(s): Martin Brunner, Thomas Straub, Pauli Saarenketo, Kari Rissanen and Ari M. P. Koskinen

Affiliation:

Keywords: amino acids, alkylation, diastereoselectivity

Abstract: Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine- 3,4-dicarboxylate (1a / b) is reported. The relative and absolute configuration of the methylated products was assigned by NOESY and confirmed by a crystal structure of 1a.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Brunner Martin, Straub Thomas, Saarenketo Pauli, Rissanen Kari and Koskinen M. P. Ari, Highly Diastereoselective Methylation of Five-Ring N,O-Acetals, Letters in Organic Chemistry 2004; 1 (3) . https://dx.doi.org/10.2174/1570178043400929