Chiral Linker 1. A Novel Chiral Auxiliary Derived from m-Hydrobenzoin as Enantiomerically Pure Linker for Solid Phase Organic Chemistry

P.      Gaertner; C.      Schuster; M.      Knollmueller

doi:10.2174/1570178043400901

Abstract

The synthesis and utility of a novel, m-hydrobenzoin derived chiral auxiliary in stereoselective α- alkylation reactions using convenient solution chemistry as well as the attachment of an analogous system onto a solid support and its application as a dual chiral auxiliary and linker is described.

Keywords: polymer support, chiral auxiliary, linker, enolate, alkylation, hydrobenzoin

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Letters in Organic Chemistry

Title: Chiral Linker 1. A Novel Chiral Auxiliary Derived from m-Hydrobenzoin as Enantiomerically Pure Linker for Solid Phase Organic Chemistry

Volume: 1 Issue: 3

Author(s): P. Gaertner, C. Schuster and M. Knollmueller

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Keywords: polymer support, chiral auxiliary, linker, enolate, alkylation, hydrobenzoin

Abstract: The synthesis and utility of a novel, m-hydrobenzoin derived chiral auxiliary in stereoselective α- alkylation reactions using convenient solution chemistry as well as the attachment of an analogous system onto a solid support and its application as a dual chiral auxiliary and linker is described.

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Gaertner P., Schuster C. and Knollmueller M., Chiral Linker 1. A Novel Chiral Auxiliary Derived from m-Hydrobenzoin as Enantiomerically Pure Linker for Solid Phase Organic Chemistry, Letters in Organic Chemistry 2004; 1 (3) . https://dx.doi.org/10.2174/1570178043400901