Synthesis of Boronated Alkoxyphenylalanines

A.      Wolan; A.      Laczynska; Z.      Rafinski; M.      Zaidlewicz

doi:10.2174/1570178043400785

Abstract

Synthesis of (2-methoxy-5-dihydroxyborylphenyl)alanine, (2-butoxy-5-dihydroxyborylphenyl) alanine, and (2-methoxy-4-dihydroxyborylphenyl)alanine for Boron Neutron Capture Therapy is described. In the key step, the amino acid functionality was introduced by the Wittig reaction. The approach provides a general access to alkoxy substituted boronated phenylalanines.

Keywords: boronated amino acids, boron neutron capture therapy, boronates, boronic acids, wittig reaction

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Letters in Organic Chemistry

Title: Synthesis of Boronated Alkoxyphenylalanines

Volume: 1 Issue: 3

Author(s): A. Wolan, A. Laczynska, Z. Rafinski and M. Zaidlewicz

Affiliation:

Keywords: boronated amino acids, boron neutron capture therapy, boronates, boronic acids, wittig reaction

Abstract: Synthesis of (2-methoxy-5-dihydroxyborylphenyl)alanine, (2-butoxy-5-dihydroxyborylphenyl) alanine, and (2-methoxy-4-dihydroxyborylphenyl)alanine for Boron Neutron Capture Therapy is described. In the key step, the amino acid functionality was introduced by the Wittig reaction. The approach provides a general access to alkoxy substituted boronated phenylalanines.

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Wolan A., Laczynska A., Rafinski Z. and Zaidlewicz M., Synthesis of Boronated Alkoxyphenylalanines, Letters in Organic Chemistry 2004; 1 (3) . https://dx.doi.org/10.2174/1570178043400785