Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy

Title: Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy

Volume: 4 Issue: 8

Author(s): Tjeerd Barf

Affiliation:

Keywords: glucocorticoid receptor, f16bpase, glycogen phosphorylase, glucagon receptor, gsk-3, g6pase

Abstract: Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.

Cite this article as:

Barf Tjeerd, Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy, Mini-Reviews in Medicinal Chemistry 2004; 4 (8) . https://dx.doi.org/10.2174/1389557043403459