Can 5-HT3 Receptor Antagonists Replace Anesthetics and Corticosteroids in the Local Treatment of Rheumatic Processes?

Title: Can 5-HT3 Receptor Antagonists Replace Anesthetics and Corticosteroids in the Local Treatment of Rheumatic Processes?

Volume: 1 Issue: 3

Author(s): Thomas Stratz and Wolfgang Muller

Affiliation:

Keywords: 5-HT3 receptors, rheumatic diseases, corticosteroids, tropiset

Abstract: A local injection of the 5-HT3 receptor antagonist tropisetron has a distinct analgesic effect on various local diseases of the locomotor system, such as tendinopathy, periarthropathy, trigger points and inflammatory articular processes. The effect of tropisetron matches that of commonly used local anesthetics like lidocaine, prilocaine and others, lasts much longer. Animal experimental and clinical findings seem to indicate that this prolonged action is most likely due to a concomitant antiinflammatory effect of the 5-HT3 receptor antagonist. It may therefore be assumed that this substance will at least partly be able to replace the administration of anesthetics and corticosteroids in the local treatment of rheumatic processes.

Cite this article as:

Stratz Thomas and Muller Wolfgang, Can 5-HT3 Receptor Antagonists Replace Anesthetics and Corticosteroids in the Local Treatment of Rheumatic Processes?, Current Rheumatology Reviews 2005; 1 (3) . https://dx.doi.org/10.2174/157339705774612274

DOI https://dx.doi.org/10.2174/157339705774612274	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360