Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755)

Title: Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755)

Volume: 2 Issue: 1

Author(s): M. Bigioni, C. Salvatore, A. Cipollone, M. Berettoni, C. A. Maggi and M. Binaschi

Affiliation:

Keywords: sabarubicin, men 10755, men 10959, men 12297, anthracycline disaccharides, dna topoisomerase

Abstract: Sabarubicin (MEN 10755) is the progenitor of a third generation of synthetic anthracycline oligosaccharides. Sabarubicin deamino analogues MEN 10959 and MEN 12297 were evaluated for topoisomerase II poisoning, cytotoxic potency and antitumor activity in human xenografts. The new analogues were able to induce DNA cleavage mediated by both DNA topoisomerase IIα and β and a good correlation was found regarding their cytotoxic activity. The two analogues possess also a different spectrum of antitumor activity, compared to sabarubicin.

Cite this article as:

Bigioni M., Salvatore C., Cipollone A., Berettoni M., Maggi A. C. and Binaschi M., Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755), Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398307

DOI https://dx.doi.org/10.2174/1570180053398307	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X