Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor

Title: Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor

Volume: 2 Issue: 1

Author(s): M. Ezawa, D. S. Garvey, D. R. Janero, S. P. Khanapure, L. G. Letts, A. Martino, R. R. Ranatunge, D. J. Schwalb and D. V. Young

Affiliation:

Keywords: cyclooxygenase, pyrazole, anti-inflammatory, cox-2, no-cox-2, no-donor

Abstract: Vicinal 1-(4-methylsulfonyl)benzene-5-(3-pyridyl) substituted pyrazole compound containing a nitric oxide (NO)-donating group at the 3-position of the pyrazole ring was synthesized and evaluated for its ability to inhibit COX isozymes in human whole blood. We report here the synthesis of 4-{3-[(1Z)-4- (nitrooxy)but-1-enyl]-5-(3-pyridyl)pyrazolyl}-1-(4-methylsulfonyl)benzene (9) and its COX-2 inhibitory potency.

Cite this article as:

Ezawa M., Garvey S. D., Janero R. D., Khanapure P. S., Letts G. L., Martino A., Ranatunge R. R., Schwalb J. D. and Young V. D., Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398451

DOI https://dx.doi.org/10.2174/1570180053398451	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X