CB1 and CB2 Cannabinoid Receptor Binding Studies Based on Modeling and Mutagenesis Approaches

Title: CB1 and CB2 Cannabinoid Receptor Binding Studies Based on Modeling and Mutagenesis Approaches

Volume: 5 Issue: 7

Author(s): Silvia Ortega-Gutierrez and Maria L. Lopez-Rodriguez

Affiliation:

Keywords: cannabinoid receptors, receptor-ligand interactions, site-directed mutagenesis, modeling studies

Abstract: In absence of X ray crystal structures of G-protein coupled receptors (GPCRs)-ligand complexes, computer-aided molecular modeling together with site-directed mutagenesis studies become of great importance in order to provide in-silico predictions that facilitate the development of new ligands. In this context, the present review addresses the application of these strategies to the CB1 and CB2 cannabinoid receptors. The combination of these complementary approaches represents a tool of considerable value which has allowed to understand the specific ligand-receptor interactions.

Cite this article as:

Ortega-Gutierrez Silvia and Lopez-Rodriguez L. Maria, CB1 and CB2 Cannabinoid Receptor Binding Studies Based on Modeling and Mutagenesis Approaches, Mini-Reviews in Medicinal Chemistry 2005; 5 (7) . https://dx.doi.org/10.2174/1389557054368754