Allosterism at Muscarinic Receptors: Ligands and Mechanisms

N.   J.M.   Birdsall; S.      Lazareno

doi:10.2174/1389557054023251

Abstract

The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity

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Mini-Reviews in Medicinal Chemistry

Title: Allosterism at Muscarinic Receptors: Ligands and Mechanisms

Volume: 5 Issue: 6

Author(s): N. J.M. Birdsall and S. Lazareno

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Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity

Abstract: The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

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Birdsall J.M. N. and Lazareno S., Allosterism at Muscarinic Receptors: Ligands and Mechanisms, Mini-Reviews in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1389557054023251