Therapeutics and Prion Disease: Can Immunisation or Drugs be Effective?

J.      Sassoon; M.      Sadowski; T.      Wisniewski; D.   R.   Brown

doi:10.2174/1389557053544065

Abstract

Prion diseases are of considerable importance because of the threat of a variant form of Creutzfeldt Jakob disease that has emerged in recent years. Pre-clinical diagnosis of prion diseases still remains poor and effective therapies also do not exist at present. This review examines research on possible therapeutic strategies that might have potential benefits if applied before neurodegeneration has occurred.

Keywords: antioxidants, immunisation, prion disease, therapeutics, transmissible spongiform encephalopathy (tse)

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Mini-Reviews in Medicinal Chemistry

Title: Therapeutics and Prion Disease: Can Immunisation or Drugs be Effective?

Volume: 5 Issue: 4

Author(s): J. Sassoon, M. Sadowski, T. Wisniewski and D. R. Brown

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Keywords: antioxidants, immunisation, prion disease, therapeutics, transmissible spongiform encephalopathy (tse)

Abstract: Prion diseases are of considerable importance because of the threat of a variant form of Creutzfeldt Jakob disease that has emerged in recent years. Pre-clinical diagnosis of prion diseases still remains poor and effective therapies also do not exist at present. This review examines research on possible therapeutic strategies that might have potential benefits if applied before neurodegeneration has occurred.

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Sassoon J., Sadowski M., Wisniewski T. and Brown R. D., Therapeutics and Prion Disease: Can Immunisation or Drugs be Effective?, Mini-Reviews in Medicinal Chemistry 2005; 5 (4) . https://dx.doi.org/10.2174/1389557053544065