Abstract
The Sonogashira cross-coupling with terminal alkynes and Buchwald coupling with aliphatic alcohols in position 6 of 2-phenylimidazo[1,2-a]pyridines was described. The position 3 was functionalized with various terminal alkynes in solution and on solid support to synthesize 3-substituted imidazo[1,2- a]pyridine derivatives.
Keywords: alkynes, 2-bromoacetophenone, copper-catalyzed coupling, cross-coupling reaction, pyridine, Iodination, palladium-coupling catalysis