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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines

Author(s): S. El Kazzouli, A. Berthault, S. Berteina-Raboin, A. Mouaddib and G. Guillaumet

Volume 2, Issue 2, 2005

Page: [184 - 187] Pages: 4

DOI: 10.2174/1570178053203017

Price: $65

Abstract

The Sonogashira cross-coupling with terminal alkynes and Buchwald coupling with aliphatic alcohols in position 6 of 2-phenylimidazo[1,2-a]pyridines was described. The position 3 was functionalized with various terminal alkynes in solution and on solid support to synthesize 3-substituted imidazo[1,2- a]pyridine derivatives.

Keywords: alkynes, 2-bromoacetophenone, copper-catalyzed coupling, cross-coupling reaction, pyridine, Iodination, palladium-coupling catalysis


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