Natural Products as Angiogenesis Modulators

K.   A.   El Sayed

doi:10.2174/138955705774575291

Abstract

Cancer remains one of the major causes of death worldwide. Anti-angiogenic therapy is one of the new approaches to anticancer therapy. Out of 22 angiogenesis inhibitors currently under clinical trials there are 11 natural products or were modeled on a natural product parent. This review shows the potential of natural products for the discovery of new anti-angiogenic leads.

Keywords: cancer, angiogenesis modulators, plant, marine, microbial natural products

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Mini-Reviews in Medicinal Chemistry

Title: Natural Products as Angiogenesis Modulators

Volume: 5 Issue: 11

Author(s): K. A. El Sayed

Affiliation:

Keywords: cancer, angiogenesis modulators, plant, marine, microbial natural products

Abstract: Cancer remains one of the major causes of death worldwide. Anti-angiogenic therapy is one of the new approaches to anticancer therapy. Out of 22 angiogenesis inhibitors currently under clinical trials there are 11 natural products or were modeled on a natural product parent. This review shows the potential of natural products for the discovery of new anti-angiogenic leads.

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El Sayed A. K., Natural Products as Angiogenesis Modulators, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575291