Antiangiogenesis by Chemotherapeutic Agents

Domenico      Ribatti; Angelo      Vacca; Francesca      Merchionne; Marco      Presta

doi:10.2174/1389557053175353

Abstract

Many tumors are not curable because current treatments primarily target the tumor cells. Intratumoral endothelial cells, on the other hand, proliferate rapidly and are sensitive to the cytotoxic effects of chemotherapeutic agents. This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors.

Keywords: angiogenesis, antiangiogenesis, chemotherapeutic agents, endothelial cells, tumor progression

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Mini-Reviews in Medicinal Chemistry

Title: Antiangiogenesis by Chemotherapeutic Agents

Volume: 5 Issue: 3

Author(s): Domenico Ribatti, Angelo Vacca, Francesca Merchionne and Marco Presta

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Keywords: angiogenesis, antiangiogenesis, chemotherapeutic agents, endothelial cells, tumor progression

Abstract: Many tumors are not curable because current treatments primarily target the tumor cells. Intratumoral endothelial cells, on the other hand, proliferate rapidly and are sensitive to the cytotoxic effects of chemotherapeutic agents. This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors.

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Ribatti Domenico, Vacca Angelo, Merchionne Francesca and Presta Marco, Antiangiogenesis by Chemotherapeutic Agents, Mini-Reviews in Medicinal Chemistry 2005; 5 (3) . https://dx.doi.org/10.2174/1389557053175353