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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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How Do Cofactors Modulate Protein Folding?

Author(s): Catherine L. Higgins, B. K. Muralidhara and Pernilla Wittung-Stafshede

Volume 12, Issue 2, 2005

Page: [165 - 170] Pages: 6

DOI: 10.2174/0929866053005782

Price: $65

Abstract

Cofactors are essential components of many proteins for biological activity. Characterization of several cofactor-binding proteins has shown that cofactors often have the ability to interact specifically with the unfolded polypeptides. This suggests that cofactor-coordination prior to polypeptide folding may be a relevant path in vivo. By binding before folding, the cofactor may affect both the mechanism and speed of folding. Here, we discuss three different cofactors that modulate protein-folding processes in vitro.

Keywords: cofactor-binding protein, azurin, flavodoxin, ferredoxin, flavin mononucleotide, iron-sulfur cluster, folding speed, folding pathway

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