1,10-Epoxyhypocretenolides from the Azorean Endemic Leontodon rigens (Asteraceae)

C.      Zidorn; E.-   P.   Ellmerer; G.      Konwalinka; K.-   H.   Ongania; R.      Schwaha; R.      Greil; K.      Joehrer; N.   B.   Perry; H.      Stuppner

doi:10.2174/1570178054406002

Abstract

A methanolic extract of Leontodon rigens (Dryander in Aiton) Paiva & Ormonde yielded 1,10- epoxy-14-hydroxyhypocretenolide-β-D-glucopyranoside and its 6-O-p-hydroxyphenylacetyl derivative. These compounds represent the first epoxyguaian-12,5-olide derivatives. The structures were established by means of high resolution mass spectrometry and 1-D and 2-D NMR spectroscopy. The cytotoxicity of the isolated compounds was assessed using the MTT assay and their potential to induce apoptosis by employing the annexin V-PI assay.

Keywords: asteraceae, leontodon rigens, natural products, sesquiterpene lactone epoxides, cytotoxicity

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: 1,10-Epoxyhypocretenolides from the Azorean Endemic Leontodon rigens (Asteraceae)

Volume: 2 Issue: 5

Author(s): C. Zidorn, E.- P. Ellmerer, G. Konwalinka, K.- H. Ongania, R. Schwaha, R. Greil, K. Joehrer, N. B. Perry and H. Stuppner

Affiliation:

Keywords: asteraceae, leontodon rigens, natural products, sesquiterpene lactone epoxides, cytotoxicity

Abstract: A methanolic extract of Leontodon rigens (Dryander in Aiton) Paiva & Ormonde yielded 1,10- epoxy-14-hydroxyhypocretenolide-β-D-glucopyranoside and its 6-O-p-hydroxyphenylacetyl derivative. These compounds represent the first epoxyguaian-12,5-olide derivatives. The structures were established by means of high resolution mass spectrometry and 1-D and 2-D NMR spectroscopy. The cytotoxicity of the isolated compounds was assessed using the MTT assay and their potential to induce apoptosis by employing the annexin V-PI assay.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Zidorn C., Ellmerer P. E.-, Konwalinka G., Ongania H. K.-, Schwaha R., Greil R., Joehrer K., Perry B. N. and Stuppner H., 1,10-Epoxyhypocretenolides from the Azorean Endemic Leontodon rigens (Asteraceae), Letters in Organic Chemistry 2005; 2 (5) . https://dx.doi.org/10.2174/1570178054406002