Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide)

Title: Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide)

Volume: 2 Issue: 5

Author(s): M. Sani, F. Viani, M. Binda, N. Zaffaroni and M. Zanda

Affiliation:

Keywords: prostate cancer, anti-androgen, trifluoro-casodex analogue, nucleophilic reagents, chromatography

Abstract: The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro antiproliferative activity on the human prostate cancer cell line LNCaP.

Cite this article as:

Sani M., Viani F., Binda M., Zaffaroni N. and Zanda M., Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide), Letters in Organic Chemistry 2005; 2 (5) . https://dx.doi.org/10.2174/1570178054405850